HIF1α and metabolic reprogramming in inflammation

HIF1α and metabolic reprogramming in inflammation.

HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably...

Metabolic Reprogramming and Inflammation Act in Concert to

HIF 1 α and metabolic reprogramming in inflammation

Introduction ATP production is required to support physiological function in all cells. Methods of ATP production vary between cell types and cellular activation states. Glucose can be used to fuel ATP production through two linked metabolic pathways: glycolysis and the TCA cycle. In glycolysis, glucose is converted into pyruvate in the cytoplasm and phosphates are transferred to ADP to generat...

EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling

Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This is called the Warburg effect, and it promotes tumorigenesis and malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor proliferation, invasion and metastasis, promotes glioblastoma tumorigenesis and malignant progres...

Metabolic Reprogramming in Glioma

Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic currency to accomplish cellular tasks. The...